Perez entered the tournament late on the back of just one warm-up contest but will now challenge Breidis for the green and gold belt and a place in the semi-finals of the World Boxing Super Series.
Murat Gassiev will battle Krzysztof Wlodarczyk in a predetermined fight due to IBF mandatory ties, whilst Aleksandr Usyk chose Marco Huck for his title defence.
That left a WBA title clash between Yunier Dorticos and Dmitry Kudryashov as the fourth bout, which will eventually see one fighter take home four world titles.
Full Draw:
Mairis Breidis v Mike Perez – WBC title
Murat Gassiev v Krzysztof Wlodarczyk – IBF title
Aleksandr Usyk v Marco Huck – WBO title
Yunier Dorticos v Dmitry Kudryashov – WBA title
Bouts to take place September/October 2017